| Momelotinib (CYT387) |
Influence on cell growth |
Trypan blue exclusion assay |
1.00 µM |
MDCK |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell growth |
Trypan blue exclusion assay |
1.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell growth |
Trypan blue exclusion assay |
2.00 µM |
MDCK |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell growth |
Trypan blue exclusion assay |
2.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell growth |
Trypan blue exclusion assay |
5.00 µM |
MDCK |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell growth |
Trypan blue exclusion assay |
5.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell growth |
MTS |
1.00 µM |
MDCK |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell growth |
MTS |
2.00 µM |
MDCK |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell growth |
MTS |
5.00 µM |
MDCK |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell growth |
MTS |
1.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell growth |
MTS |
2.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell growth |
MTS |
5.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
CellTiter96 AQueous One Solution Cell Proliferation assays |
1.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
CellTiter96 AQueous One Solution Cell Proliferation assays |
2.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
CellTiter96 AQueous One Solution Cell Proliferation assays |
5.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
2.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
4.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
6.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
8.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
1.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 1 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
2.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 1 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
3.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 1 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
4.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 1 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
5.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 1 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
1.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 2 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
2.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 2 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
3.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 2 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
4.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 2 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
5.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 2 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
1.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 3 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
2.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 3 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
3.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 3 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
4.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 3 |
|
|
| Momelotinib (CYT387) |
Influence on cell proliferation |
MTS |
5.00 µM |
DLBCL primary cells |
Canis familriaris |
patient 3 |
|
|
| Momelotinib (CYT387) |
Influence on RNA expression |
RT-qPCR |
N/A µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on RNA expression |
RT-qPCR |
N/A µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on protein activity |
Western Blot |
1.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on protein activity |
Western Blot |
2.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on protein activity |
Western Blot |
5.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on protein activity |
Western Blot |
1.00 µM |
CLBL-1 |
Canis familriaris |
|
p-STAT3 |
|
| Momelotinib (CYT387) |
Influence on protein activity |
Western Blot |
2.00 µM |
CLBL-1 |
Canis familriaris |
|
p-STAT3 |
|
| Momelotinib (CYT387) |
Influence on protein activity |
Western Blot |
5.00 µM |
CLBL-1 |
Canis familriaris |
|
p-STAT3 |
|
| Momelotinib (CYT387) |
Influence on protein activity |
Western Blot |
1.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on protein activity |
Western Blot |
2.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on protein activity |
Western Blot |
5.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on STAT3 activity in presence of IL6 |
Flow cytometry |
1.50 µM |
CLBL-1 |
Canis familriaris |
|
p-STAT3 |
|
| Momelotinib (CYT387) |
Influence on STAT3 activity in presence of IL6 |
MFI |
1.50 µM |
CLBL-1 |
Canis familriaris |
|
p-STAT3 |
|
| Momelotinib (CYT387) |
Influence on cell apoptosis |
Flow cytometry |
1.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell apoptosis |
Flow cytometry |
5.00 µM |
CLBL-1 |
Canis familriaris |
|
|
|
| Momelotinib (CYT387) |
Influence on cell apoptosis |
Flow cytometry |
1.00 µM |
MDCK |
Canis familriaris |
|
|
|
